Foldiff — protein engineeringhttps://oligoplan.ru/en/articles/Practical articles with sourcesenEnzyme stabilization: choosing the first substitution serieshttps://oligoplan.ru/en/articles/enzyme-stabilization-first-series/https://oligoplan.ru/en/articles/enzyme-stabilization-first-series/From a public protein and homolog to candidates, WT controls and measurements. What to check before mutagenesis.Fri, 02 Oct 2026 05:45:00 GMTΔΔG and Tm: why predictions cannot be converted to degreeshttps://oligoplan.ru/en/articles/ddg-and-tm/https://oligoplan.ru/en/articles/ddg-and-tm/Read the ΔΔG sign in Foldiff, distinguish predictions from melting temperature and assess model disagreements.Fri, 02 Oct 2026 05:45:00 GMTpLDDT and PAE: interpreting AlphaFold structure confidencehttps://oligoplan.ru/en/articles/alphafold-confidence/https://oligoplan.ru/en/articles/alphafold-confidence/How pLDDT and PAE differ, what structure confidence means and how Foldiff uses existing AlphaFold DB models.Fri, 02 Oct 2026 05:45:00 GMTpH experiment: from measurements to the observed maximumhttps://oligoplan.ru/en/articles/ph-experiment/https://oligoplan.ru/en/articles/ph-experiment/Set a pH range, import CSV, interpret means and SD, and choose the next measurement series in Foldiff.Fri, 02 Oct 2026 05:45:00 GMTFireProtDB 2.0: why more data do not make every prediction more accuratehttps://oligoplan.ru/en/articles/fireprotdb-2-data/https://oligoplan.ru/en/articles/fireprotdb-2-data/What changed in FireProtDB 2.0 and why measurement type, construct and overlap with model training matter.Fri, 02 Oct 2026 05:45:00 GMT